Day-One Handout

Tirzepatide — Day One

Day-one Tirzepatide reference: dose schedule, titration timing, and the side-effect playbook for the first eight weeks.

Impact Health | Patient Guide
Performance medicine built for results
Starting Tirzepatide
Dual GIP/GLP-1 weekly injection: how to use, what to expect, and safety signals.
Quick start
  • Once-weekly subQ, same day each week; rotate abdomen, thigh, or upper arm.
  • Follow the titration plan—appetite effects can feel brisk early.
  • Small, protein-first meals; sip fluids through the day.
Why it works

Tirzepatide activates both GIP and GLP-1 receptors to enhance satiety, slow gastric emptying, and improve glycemic control, often delivering early appetite reduction.

How to take it

Weekly injection

  • Choose one weekly day; rotate sites; clean skin; inject slowly.
  • Use fresh needle each time; dispose in sharps container.
  • Store pens refrigerated; protect from heat/freezing.

Missed dose

  • If within 4 days of your usual day, take it; if >4 days, skip and resume on the next scheduled day.
  • Never double doses.

GI comfort

  • Slow eating, smaller portions; avoid greasy or very sugary meals.
  • Prioritize lean protein, vegetables, fiber; walk after meals.
  • Hydrate consistently; consider electrolytes if advised.

What to expect by week

Weeks 0–2 Noticeable appetite reduction is common; mild nausea or fullness possible.
Weeks 2–8 Weight change often begins; GI effects usually ease with pacing and hydration.
8+ weeks Continued weight and metabolic improvements as habits and dosing stabilize.
Monitoring
  • Titration check-ins typically every 4–8 weeks.
  • Labs per plan (glycemic markers, lipids, metabolic panel) and vitals as indicated.
  • Track appetite, weight, hydration, GI symptoms.
Common, usually mild
  • Nausea, early fullness, constipation or loose stools, reflux.
  • Injection-site redness/itch (should remain mild and brief).

Call us immediately

  • Severe or persistent abdominal pain, especially with nausea/vomiting.
  • Unable to keep fluids down; signs of dehydration or dizziness.
  • Yellowing skin/eyes or sharp right-upper abdominal pain.
  • Allergic reaction: swelling, rash, breathing difficulty.

Phone (662) 404-7177  |  impacthealthclinics.com  |  info@impacthealthclinics.com

Habits that amplify results
  • Protein target ~0.7–1.0 g/lb goal body weight (per clinician guidance).
  • Daily hydration and fiber; light movement after meals.
  • Resistance training 2–4x/week to preserve lean mass.
  • Limit alcohol; separate caffeine from late meals.

FAQs

  • Travel? Keep pens cool (not frozen) with an ice pack in carry-on; store needles safely; maintain your weekly day.
  • Constipation? Hydrate, add fiber, walk daily; ask before OTC aids.
  • Can I pause doses? Do not change or pause without clinician guidance; appetite may rebound and GI effects can return if restarted high.

This guide is educational and not a substitute for medical advice. Follow your clinician’s instructions.